Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B
نویسندگان
چکیده
منابع مشابه
Selection of Nanobodies that Target Human Neonatal Fc Receptor
FcRn is a key player in several immunological and non-immunological processes, as it mediates maternal-fetal transfer of IgG, regulates the serum persistence of IgG and albumin, and transports both ligands between different cellular compartments. In addition, FcRn enhances antigen presentation. Thus, there is an intense interest in studies of how FcRn binds and transports its cargo within and a...
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The neonatal Fc receptor, FcRn mediates an endocytic salvage pathway that prevents degradation of IgG, thus contributing to the homeostasis of circulating IgG. Based on the low affinity of IgG for FcRn at neutral pH, internalization of IgG by endothelial cells is generally believed to occur via fluid-phase endocytosis. To investigate the role of FcRn in IgG internalization, we used quantitative...
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ژورنال
عنوان ژورنال: Cell
سال: 2019
ISSN: 0092-8674
DOI: 10.1016/j.cell.2019.04.035